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OBJECTIVE: To analyze the effect of bronchoalveolar lavage( BAL) on respiratory function and arterial blood gas of pneumoconiosis patients. METHODS: The published literatures about relationship between BAL and respiratory function and arterial blood gas in pneumoconiosis patients from China National Knowledge Internet,Wanfang Database,Chinese Biomedical Literature Database,Chinese Journal Database,Pub Med,Embase,Web of Science Database and the Cochrane Library Database and so on from 2000 to 2016 were retrieved,collected,and screened by using bibliometric method. The data was analyzed by Meta analysis with the help of Rev Man 5. 0 software. The weighted mean difference( MD) and 95%confidence interval( CI) were calculated on selected literatures. RESULTS: A total of 20 articles were selected and used.The forced vital capacity( FVC)( MD = 0. 21,95% CI: 0. 04-0. 37),the forced expiratory volume in one second( FEV1)( MD = 0. 12,95% CI: 0. 01-0. 23),the maximum ventilatory volume( MD = 10. 73,95% CI: 3. 48-17. 98) and partial pressure of oxygen( MD = 8. 85,95% CI: 0. 30-17. 39) in the patients after BAL were higher than before( P < 0. 05),while the partial pressure of carbon dioxide in artery( MD =-3. 58,95% CI:-5. 61--1. 55) decreased( P < 0. 01).Both of the FEV1/FVC( MD = 2. 08,95% CI:-6. 27-10. 43) and the FEV1%( MD = 0. 86,95% CI:-0. 55-2. 28)had not statistically significance before and after BAL( P > 0. 05). CONCLUSION: BAL can improved respiratory function and arterial blood gas in pneumoconiosis patients.
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Objective To explore the effects of lead acetate on free radicals and lipid peroxidation in the cerebral cor?tex, cerebellum, and hippocampus in rat brains. Methods SD rats (n=48), who were just weaned, were randomly divided in?to 4 groups base on their weight. Then the rats were fed with lead acetate in drinking water at the final concentrations of 0 mg/L (deionized water), 200 mg/L, 400 mg/L, 800 mg/L respectively. Blood lead level as well as the hydroxyl free radical inhibiting activity, the levels of hydrogen peroxide (H2O2) and malondialdehyde (MDA) in cerebral cortex, cerebellum, and hippocam?pus were measured 60 days after lead contamination in water. Results Upon lead exposure, blood lead levels increased sig?nificantly as compared with the control. The hydroxyl free radical inhibiting activity in cerebral cortex, cerebellum, and hip?pocampus decreased significantly in a dose dependent manner of lead(P < 0.05). And they all correlated negatively with blood lead level (r=-0.505,-0.414,-0.448, P<0.05). By contrast, blood lead level was positively correlated with H2O2 and MDA in these brain tissues (r=0.301, 0.411, 0.378, and 0.404, 0.324, 0.510,P < 0.05). Conclusion Lead exposure can lead to lipid peroxidation of rat brain tissues through inducing free radicals.
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Objective To discover,diagnose and treat colorectal cancer in the early period and further improve the survival rate,reduce morbidity and mortality of the colorectal cancer by early screening for colorectal cancer in Jinjiang.Methods According to “The Guide of Cancer Screening and Early Diagnosis and Treatment in China by the Experts Group of Ministry of Health”,the case history was collected while the stool occult blood and FOBT were detected to discover high risk crowd who then inspected by electron enterscope.Results The screening was practiced in Xibin,Zimao and Neikeng town respectively.The crowd of 40-74 years old was 10 116 and 2631 of them accepted screening(acclimation rate,26％).Two hundred and fifty-seven high-risk people were discovered(9.8％ of 2631)and 86 of them(acclimation rate,33％,86/257)were inspected by electron enterscope.Twenty-two cases were detected with colorectal affection(detection rate,8.6％,22/257),20 cases were diagnosed as colorectal adenoma and 2 cases were diagnosed as adenocarcinoma by pathological section.All of them accepted therapy.Conclusion Carrying out early screening for colorectal cancer is important.It can reduce morbidity and mortality of the colorectal cancer and then improve the cure rate and prolong survival in patients with colorectal cancer.
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Objective To observe the effect of oxymatrine on the Absorption of carbohydrate and fat and the activity of peroxisome proliferator activated receptor ? and ?.Methods 64 masculine SD rats were randomly divided into three groups,20 sugar tolerance test,20 triacylglycero Absorption test and 24 oxymatrine effecting on triacylglycero and cholesterin test,and observed the effect of oxymatrine on glycosidase activity,blood sugar and activity of peroxisome proliferator activated receptor ? and ?.Results ① The depressant effect of oxymatrine on the activity of glycosidase was strengthened by the increased dosage.② Oxymatrine could suppress the upgraded level of blood sugar after took amylon and cane-sugar,and inhibit the upgraded level of triacylglycerol after feed by olive oil and hypso-cholesterol,but did not suppress the upgraded level of blood sugar after took glucose and hardly influence the level of high density lipoprotein cholesterol and low density lipoprotein cholesterol.③ Oxymatrine could obviously activate the activity of peroxisome proliferator activated receptor ? and ?,the activity of peroxisome proliferator activated receptor ? and ? increased gradually by the augment of the oxymatrine,and expressed evident dose-response relation.Conclusions Oxymatrine could not only directly inhibit the Absorption of triacylglycerol and depress the elevated level of postprandial triacylglycerol,but also activate peroxisome proliferator activated receptor ?,moreover possess dose-response relation.
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Objective:To study the relationship between body image and s ubjective happiness Method:225 female students of a normal scho ol in Nanchang were tested with self-designed self-image scale, the index of the ir body (height, weight ) were also collected Results:In 5 8 6% of our sample, there was a obvious difference between the self-judgement of sel f-image and the result of body index, 11 4% had disturbance of body image Bet we en those with disturbance and those without, there were significant differences in desire to be slim, fitness of self, and ideal body image There was signific a nt correlation between satisfaction of fitness of oneself and subjective happine ss, between self-induced vomiting and using drugs in fitness Conclusion : Girls with disturbance
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OBJECTIVE:To prepare red sage gel for implantation and to establish a method for its quality control.METHODS:With carbamer934as vehicle,2%red sage gel was prepared;a HPLC method for the determination of tanshinone in gel was established.RESULTS:The calibration curve of tanshinoneⅡ A was linear in the concentration range of16.59～33.18ng/ml,Y=9723X—2569(n=5),r=0.9987.CONCLUSION:The preparation of red sage gel was simple,its quality was stable;the method of quality control was rapid and accurate.
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OBJECTIVE:To establish a HPLC method to determine the content of compound tramadol tablets METHODS:Stationary phase:Kromasil C18 column,internal standard:phenacetin,mobile phase:methanol-water-triethlamine(55∶45∶0 2),adjusting pH to 4 2 with acetic acid,flow rate∶0 7ml/min,detecting wavelength∶267nm RESULTS:The linear range of tramadol (TR) was 50～500?g/ml(r=0 9 999,n=5) The linear range of nefopam(NFP) was 50～500?g/ml(r=0 9 999,n=5) The average recovery of TR was 99 69% The average content of TR was 100 71%,RSD=0 76%(n=5) The average recovery of NFP was 99 76% The average content of NFP was 99 64%,RSD=0 62%(n=5) CONCLUSION:The method is accurate,rapid and simple